Research Paper Volume 12, Issue 10 pp 9745—9760

Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells

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Figure 4. HPLC analysis of metabolites in CTL and macroH2A1 KD UM 92.1 cells. (A) Heatmap representing the levels of major classes of metabolites detected by HPLC. (B) Acetyl-co-A levels; (C) NADP+ levels; (D) NADPH levels; (E) NADP+/NADPH levels; (F) NAD+/NADH levels. Results are presented as the mean ± SEM of four independent experiments. (*p < 0.01; *** p < 0.001 vs control).