Research Paper Volume 12, Issue 10 pp 9745—9760

Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells

Figure 4. HPLC analysis of metabolites in CTL and macroH2A1 KD UM 92.1 cells. (A) Heatmap representing the levels of major classes of metabolites detected by HPLC. (B) Acetyl-co-A levels; (C) NADP+ levels; (D) NADPH levels; (E) NADP+/NADPH levels; (F) NAD+/NADH levels. Results are presented as the mean ± SEM of four independent experiments. (*p < 0.01; *** p < 0.001 vs control).