Research Paper Volume 12, Issue 10 pp 9761—9780

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

Figure 10. GH-deficiency results in decreased absolute metabolic rate. Overall averaged energy expenditure of WT and GHRH-/- are shown as light (72 hours; A, B) and dark cycles (72 hours; C, D). WT female n=12, KO female n=12, WT male n=12, KO male n=11. Each bar represents mean. Statistical analysis was performed by Student’s t-test with Welch’s correction; ****p<0.0001.