Research Paper Volume 12, Issue 10 pp 9761—9780

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

Figure 6. Absolute VO2 and VCO2 recordings in GHRH-/ mice. VO2 and VCO2 were measured by indirect calorimetry. Hourly averages of respiratory parameters measured for 6 days for female (A, E) and male (B, F) WT and GHRH-/- mice. 6 days of VO2 and VCO2 data were averaged into a single day for female (C, G) and male (D, H) WT and GHRH-/- mice. Female WT n=12, GHRH-/- n=12, male WT n=12, GHRH-/- n=11. Each bar represents mean ± SEM.