Research Paper Volume 12, Issue 10 pp 9781—9792

LncRNA DSCAM-AS1 promotes colorectal cancer progression by acting as a molecular sponge of miR-384 to modulate AKT3 expression

Figure 6. Knockdown of DSCAM-AS1 suppressed tumor growth in vivo. (A) Tumor growth curves were calculated in nude mice after subcutaneously injection of DSCAM-AS1-depletion LOVO cells. (B) Representative image of isolated tumor from nude mice. (C) The tumor weights were examined in isolated tumor from nude mice. (D) The expression of Ki-67 was measured in tumors derived from mice by immunostaining. (E, F) The expression of DSCAM-AS1 and miR-384 were examined in xenografted tumor by qRT-PCR. (G, H) The expression of AKT3 on mRNA and protein levels was measured in xenografted tumor. P< 0.05, **P < 0.01.