Research Paper Volume 12, Issue 10 pp 9807—9824

Identification and validation of hub microRNAs dysregulated in esophageal squamous cell carcinoma

Figure 4. Regulatory networks of miRNAs-hub-gene targets. (A) Interaction network of the three upregulated miRNAs and their hub-gene targets. (B) Regulatory network of the five downregulated miRNAs and their hub-gene targets. (CD) Regulatory networks of miR-196a-5p and miR-1-3p and associated signaling pathways.