Research Paper Volume 12, Issue 13 pp 12812—12840

PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer

Figure 12. The attenuation of PHLPP2 on tumor metastasis and formation is enhanced by the overexpression of LINC00402, LINC00461 and SFTA1P or reduced by miR-141 and miR-424. Nude mice were injected with cell suspension carrying HT-29 cells transfected with NC, PHLPP2, PHLPP2 + miR-141, PHLPP2 + miR-424, PHLPP2 + LINC00402, PHLPP2 + LINC00461 or PHLPP2 + SFTA1P. (A) Representative images of the liver lesion in the liver tissues of nude mice. (B) HE staining of liver tissues (100 ×) in nude mice revealed the number of liver metastatic nodules. (C) The numbers of liver metastatic nodules in nude mice 8 weeks counted by HE staining. * p < 0.05 vs. the NC group; # p < 0.05 vs. the PHLPP2 group. Measurement data in this Figure were expressed as the mean ± standard deviation, and comparisons among multiple groups were conducted by One-Way ANOVA (n = 5); the experiment was repeated three times independently.