Figure 12. The attenuation of PHLPP2 on tumor metastasis and formation is enhanced by the overexpression of LINC00402, LINC00461 and SFTA1P or reduced by miR-141 and miR-424. Nude mice were injected with cell suspension carrying HT-29 cells transfected with NC, PHLPP2, PHLPP2 + miR-141, PHLPP2 + miR-424, PHLPP2 + LINC00402, PHLPP2 + LINC00461 or PHLPP2 + SFTA1P. (A) Representative images of the liver lesion in the liver tissues of nude mice. (B) HE staining of liver tissues (100 ×) in nude mice revealed the number of liver metastatic nodules. (C) The numbers of liver metastatic nodules in nude mice 8 weeks counted by HE staining. * p < 0.05 vs. the NC group; # p < 0.05 vs. the PHLPP2 group. Measurement data in this Figure were expressed as the mean ± standard deviation, and comparisons among multiple groups were conducted by One-Way ANOVA (n = 5); the experiment was repeated three times independently.