Research Paper Volume 12, Issue 13 pp 12812—12840

PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer

Figure 13. Regulatory mechanisms of LINC00402, LINC00461, SFTA1P, miR-141, miR-424 and PHLPP2 in colon cancer progression and metastasis. LINC00402 and LINC00461 competitively bind to miR-141, and SFTA1P competitively binds to miR-424 to regulate the transcription and translation of PHLPP2, thereby suppressing the proliferation, EMT process, migration, and invasion, preventing liver metastasis of colon cancer cells.