**Figure 3.** **The expression of PHLPP2 decreases while that of miR-141 and miR-424 increases in colon cancer tissues.** (**A**) Measurement of the expression of PHLPP2 mRNA in colon cancer tissues and adjacent tissues by RT-qPCR. (**B**) Determination of the expression of miR-141 in colon cancer tissues and adjacent tissues by RT-qPCR. (**C**) Determination of the expression of miR-424 in colon cancer tissues and adjacent tissues by RT-qPCR. (**D**) Pearson’s Correlation analysis of PHLPP2 and miR-141 in colon cancer. (**E**) Pearson’s Correlation analysis of PHLPP2 and miR-424 in colon cancer. (**F**) Survival time of patients with high and low expression of PHLPP2 analyzed by Kaplan-Meier survival analysis. (**G**) Immunohistochemistry and ISH were applied to identify the expression of PHLPP2, miR-141, and miR-424 in colon cancer tissues and adjacent tissues (200 ×). * *p* < 0.05 *vs.* the adjacent tissues; Measurement data in this Figure are expressed as the mean ± standard deviation, with the comparisons between the two groups conducted using paired *t*-test, n = 135; the experiment was repeated three times independently.