Research Paper Volume 12, Issue 19 pp 18970—18981

LINC00963 facilitates acute myeloid leukemia development by modulating miR-608/MMP-15

Figure 5. LINC00963 inhibited miR-608 expression in AML cells. (A) An online database (starBase) predicted that miR-608 was a potential target of LINC00963. (B) The level of miR-608 was determined by RT-qPCR. (C) Luciferase reporter assays verified that elevated expression of miR-608 decreased the luciferase value in the LINC00963-wt group but did not change the luciferase value in the LINC00963-mut group. (D) Overexpression of LINC00963 suppressed miR-608 levels in THP-1 cells. **p<0.01. U6 was used as the internal control.