Research Paper Volume 12, Issue 19 pp 18970—18981

LINC00963 facilitates acute myeloid leukemia development by modulating miR-608/MMP-15

Figure 7. Ectopic expression of LINC00963 increased cell growth and EMT development by modulating MMP-15. (A) The level of MMP-15 was determined by RT-qPCR. (B) CCK-8 assay was performed to detect cell proliferation. (C) The level of ki-67 was measured by RT-qPCR. (D) The expression of PCNA was measured by RT-qPCR. (E) Downregulation of MMP-15 suppressed Vimentin, N-cadherin and ZEB1 levels and upregulated E-cadherin expression in LINC00963-overexpressing THP-1 cells. *p<0.05 and**p<0.01. GAPDH was used as the internal control.