Research Paper Volume 12, Issue 10 pp 9915—9934

ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer

Figure 1. Upregulation of ZNF139 in BC tissues and its correlation with the prognosis of BC patients. (A) The transcript expressions of ZNF139 were significantly higher in bladder urothelial carcinoma at varied stages (Stage I, II, III, IV) than in adjacent normal as analyzed in CRN database (http://syslab4.nchu.edu.tw). (B) Box plots showed expression of ZKSCAN1 (namely ZNF139) at mRNA level in Dyrskjot Bladder 3 (left panel) and Sanchez-Carbayo Bladder 2 (right panel), respectively. The shown indicators include over-expression gene rank, associated P values, statistical analysis and fold change according to Oncomine (www.oncomine.org). The association of ZNF139 expression with the disease-free survival was analyzed by (C) cBioPortal database (http://cbioportal.org) and (D) GEPIA database (http://gepia.cancer-pku.cn/). ZNF139, zinc finger with KRAB and SCAN domains 1; BC, bladder cancer; CRN, CancerRNA-Seq Nexus.