Research Paper Volume 12, Issue 10 pp 9948—9958

Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway

Figure 4. Down-regulation of TopBP1 induced cell apoptosis. (A) The expressions of ATR and Chk1 were decreased, followed by the decreased phosphoralation of ATR and Chk1. (B, C) The data presented are mean ± SD for at least three independent experiments. *P<0.05 compared with NC, **P<0.01 compared with NC.