Figure 4. Annotation of genus level for the thirty most abundant species determined by 16S rRNA sequencing following ovariectomy. Microbiota in red font shows significant differences between OVX0 and OVX12 (A). Heat map of the microbial communities of samples were analyzed in genus level, OUT=0.03 (B). The abundant differences of genus comparison between pre- and post-ovariectomy (C). Species abundance changes of the ten most abundant genus following ovariectomy with significant differences (D). Values were analyzed using the Kruskal-Wallis H test with Benjamini-Hochberg FDR multiple test correction, *q<0.01.