Research Paper Volume 12, Issue 20 pp 20047—20068

CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer

Figure 9. Schematic mechanism underlying CUEDC1-suppressed NSCLC progression. CUEDC1 interacts and upregulates Smurf2 expression; then, Smurf2 inactivates the TβRI/Smad signaling pathway, thereby reversing EMT and reducing the ability for tumor metastasis, inhibiting cell cycle progression, and promoting cell apoptosis to suppress tumor growth.