Research Paper Volume 12, Issue 13 pp 12869—12895

miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression


Figure 4. Treatment with miR-183-5p alleviated oxidative damage after intracerebral hemorrhaging (ICH). (A) Representative immunofluorescence images showing hydroethidine-positive reactive oxygen species (ROS) (n = 8/group) and ferrous deposition stained with Lillie dye (n = 8/group) in different groups at 3 days after ICH. Arrows indicate ferrous deposition in cells. Quantitative analysis of ROS fluorescence intensity and ferrous deposition in cells corresponding to the above are shown below. Scale bars = 50 μm. (B) Quantitative analysis of 4-HNE in the brains of mice from different groups at 3 days after ICH. n = 8/group. Values are presented as the mean ± standard deviation. *P < 0.05 vs. the ICH group.