Research Paper Volume 12, Issue 13 pp 12869—12895

miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression


Figure 7. miR-183-5p regulated heme oxygenase-1 (HO-1) independent of Nrf2. (A) Western blotting revealed that miRNA-183-5p is an HO-1–dependent inhibitor of Nrf2 phosphorylation. n = 8/group. (B) Quantitative analysis of the relative expression of p-Nrf2 protein in (A). (C) Quantitative analysis of the HO-1–dependent inhibitory effect of Nrf2 on miR-183-5p by RT-qPCR. n = 8/group. Values are presented as the mean ± standard deviation. *P < 0.05 vs. the intracerebral hemorrhaging (ICH) group. ZnPP, zinc protoporphyrin IX; tBHQ, tert-butylhydroquinone.