Research Paper Volume 12, Issue 13 pp 12896—12920

A novel molecular-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma

Figure 2. Prognostic DElncRNAs identification process. (A) Volcano plot of differentially expressed lncRNAs in TCGA-LICH dataset; (B) Hierarchical clustering of HCC with or without tumor using 669 differentially expressed lncRNAs using Euclidean distance and average linkage clustering; (C) Venn diagram of prognostic DElncRNAs in prognostic lncRNAs (OS/recurrence multivariate cox p < 0.05) and DElncRNAs(|logFC| >2 and padj < 0.05); (D) Venn diagram of lncRNAs related to OS/recurrence. TCGA, The Cancer Genome Atlas; LICH, Liver hepatocellular carcinoma; HCC, hepatocellular carcinoma; DElncRNA, differentially expressed long non-coding RNA; OS, overall survival; LASSO, least absolute shrinkage and selection operator method.