Research Paper Volume 12, Issue 13 pp 12921—12929

Relationship between the expression of oestrogen receptor and progesterone receptor and 18F-FDG uptake in endometrial cancer

Figure 1. The association between 18F-FDG accumulation and ER/PR status in endometrial cancers (n = 62). (A) The association between 18F-FDG accumulation and ER status. Endometrial cancers in the ER-positive group had lower SUVmax than those in the ER-negative group (12.3 ± 6.2 vs. 19.9 ± 6.6, respectively; P = 0.003). (B) The association between 18F-FDG accumulation and PR status. Endometrial cancers in the PR-positive group also had lower SUVmax than those in the PR-negative group (12.4 ± 6.2 vs. 20.0 ± 6.9, respectively; P = 0.005). (C) ROC analysis of SUVmax for predicting ER status. When the cutoff threshold of SUVmax was 15.3, the sensitivity and specificity to predict ER expression were 73.1% and 80.0%, respectively. The area under curve was 0.8 (95% confidence interval: 0.679-0.921; P = 0.003). (D) ROC analysis of SUVmax for predicting PR status. When the cutoff threshold of SUVmax was 15.95, the sensitivity and specificity to predict PR expression were 73.6% and 77.8%, respectively. The area under curve was 0.792 (95% confidence interval: 0.663-0.992; P = 0.005).