Priority Research Paper Volume 12, Issue 11 pp 10041—10058

Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster

Figure 3. Adult specific overexpression of Ldh shortens fly lifespan. (AF) Survival curves of adult males overexpressing Ldh in all clock cells via timts (A, D), in neurons via elavts (B, E), or in glia via repots (C, F) each graphed relative to their control group at 27°C and 25°C, respectively. Overexpression of Ldh via each driver resulted in decreased median lifespan compared to their respective controls in both 27°C and 25°C (Gehan-Breslow-Wilcoxon test; p<0.05 for graphs B and C and p<0.0001 for graphs A, D, E, and F). See Supporting Information Supplementary Table 2 for experimental details.