Figure 5. Decreased Ldh expression in adult brain extended lifespan. Survival curves of males with reduced Ldh expression via LdhRNAi combined with timts (A, D), elavts (B, E), or repots (C, F) and their controls at 27°C and 25°C, respectively. Ldh decrease significantly extends lifespan compared to controls (pairwise comparison by Gehan-Breslow-Wilcoxon test yielded p<0.0001 for all graphs except p<0.05 for repots> LdhRNAi versus control at 25°C). See Supporting Information Supplementary Table 3 for experimental details.