Research Paper Volume 12, Issue 13 pp 13115—13127

ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling

Figure 1. High ROR2 expression correlates with poor clinical outcome in BC patients. (A) ROR2 mRNA levels in 45 pairs of BC tissues compared with corresponding adjacent normal tissues. (B) Kaplan-Meier DFS curves for 45 BC patients classified according to ROR2 mRNA levels. (C, D) ROR2 expression analyzed by qRT-PCR (C) and Western blotting (D) in MDA-MB-231 and MCF-7 cells transfected with siROR2 and pLenti-ROR2 plasmids. Image J software (version 1.48, NIH, USA) was used for the quantitative analysis of ROR2 protein levels analyzed by western blotting. Results are shown as means ± SD, n=3; *p<0.05, **p<0.01, ***p<0.001.