Research Paper Volume 12, Issue 13 pp 13115—13127

ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling

Figure 2. ROR2 promotes BC cell proliferation in vitro. (A, B) Cell proliferation analyzed by CCK-8 assay in MDA-MB-231 (A) and MCF-7 (B) cells transfected with ROR2 siRNA and overexpression plasmids. (C, D) Colony formation assay of ROR2 effect on MDA-MB-231 and MCF-7 cell proliferation. (E, F) Flow cytometry analysis of apoptosis of MDA-MB-231 and MCF-7 cells after siROR2 and pLenti-ROR2 transfection. Results are shown as means ± SD; n=3; *p<0.05, **p<0.01.