Research Paper Volume 12, Issue 13 pp 13115—13127

ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling

Figure 6. ROR2 induces PI3K/AKT signaling in vivo. (A) qRT-PCR of Bax, Bak, Bcl-2, Bcl-xl, mTOR, and survivin 1 in MDA-MB-231 xenografts with ROR2 knockdown, and in ROR2-overexpressing MCF-7 xenografts. (B) qRT-PCR of PI3K, AKT, pAKT, PDK1, p21, and cyclin D1 in the above tumors. Results are shown as means ± SD; n=3; *p<0.05, **p<0.01.