Research Paper Volume 12, Issue 12 pp 12251—12267

Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survival

Figure 8. Post-ischemic neurodegeneration of neurons in seven investigated regions of the rat brain upon 2 years of survival. Neurons were immuno-labeled with NeuN, as a neuronal marker, and with Fluoro Jade C, as a marker of deteriorating neurons. The graph shows the quantitative analysis of the coefficient of colocalisation of the two markers in control (Ctrl) and ischemic (Isch) sections in various brain regions studied. DG - dentate gyrus, CA1 and CA3 regions of the hippocampus, LD - dorso-lateral nucleus of thalami, STR-CP - striatum-caudoputamen, pMO - primary motor cortex, pSS - primary somatosensory cortex. Data are presented as mean ± SEM.