Research Paper Volume 12, Issue 13 pp 13206—13219

Altered circular RNA expression profiles in the non-ischemic thalamus in focal cortical infarction mice

Figure 2. Altered expression profile of circRNAs in the ipsilateral thalamus after focal cortical infarction in adult mice. (A, B) The hierarchical clustering analyses of all differentially expressed circRNAs in the ipsilateral thalamus in the sham and distal middle cerebral artery occlusion (MCAO) groups: Red represents a higher fold change and blue represents a lower fold change. (C, D) The volcano plots of all the detected circRNAs in both the sham and MCAO groups: The vertical line represents to |log 2 (fold change) | > 1 up and down, respectively, and the horizontal line corresponds to a p-value of 0.05 (−log10 scaled). The red points represent the differentially up-regulated circRNAs and the green point represents the significantly down-regulated circRNAs with statistical significance. (EG) The validation results of mmu_circ:chr2:74568941-74573626, mmu_circ:chr8:8639206-8639489, and mmu_circ:chr18:14633543-14636618 by qRT-PCR in the sham and MCAO groups (n=6 each).