**Figure 2.** **Altered expression profile of circRNAs in the ipsilateral thalamus after focal cortical infarction in adult mice.** (**A**, **B**) The hierarchical clustering analyses of all differentially expressed circRNAs in the ipsilateral thalamus in the sham and distal middle cerebral artery occlusion (MCAO) groups: Red represents a higher fold change and blue represents a lower fold change. (**C**, **D**) The volcano plots of all the detected circRNAs in both the sham and MCAO groups: The vertical line represents to |log 2 (fold change) | > 1 up and down, respectively, and the horizontal line corresponds to a p-value of 0.05 (−log10 scaled). The red points represent the differentially up-regulated circRNAs and the green point represents the significantly down-regulated circRNAs with statistical significance. (**E**–**G**) The validation results of mmu_circ:chr2:74568941-74573626, mmu_circ:chr8:8639206-8639489, and mmu_circ:chr18:14633543-14636618 by qRT-PCR in the sham and MCAO groups (n=6 each).