Research Paper Volume 12, Issue 15 pp 15290—15301

Neutrophil depletion enhances the therapeutic effect of PD-1 antibody on glioma

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Figure 5.

Tumors with higher PD-L1 expression were associated with a poor clinical outcome in the Sanbo cohort (p =0.017, (A). Tumor-infiltrating neutrophils (TINs) were significantly increased in tumors with PD-L1 positivity (p = 0.005, (B). Spearman correlation between TINs and PD-L1 mRNA levels showed that PD-L1 transcript levels were significantly positive with TINs in TCGA (p < 0.001, (C) and CGGA cohorts (p < 0.001, (D).