Research Paper Volume 12, Issue 13 pp 13338—13353

circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway

Figure 1. circRNA_100859 is significantly overexpressed in colon cancer and verified by RT-qPCR (n=3). (A) The heat mapping revealed the top ten significantly increased and decreased circRNAs. (B) RT-qPCR assay verifies that it significantly over-expressed in colon cancer tissues (n=50), compared with adjacent non-cancer tissues. (C) Matched pair analysis showed the expression of circRNA_100859 in colon cancer tissues was mostly higher than corresponding adjacent non-cancer tissues. N: adjacent non-cancer tissues, C: colon cancer tissues.