Research Paper Volume 12, Issue 13 pp 13422—13436

Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice

Figure 3. CPPs treatment prevented Aβ accumulation in APP/PS1 mice. (A) Western blotting was performed to detect the expression of APPβ, BACE1 and APPα proteins in the hippocampus. (BD) Quantitative analysis of the blots. (E) Relative fluorescence levels of BACE1 were detected in the hippocampal lysate. (F, G) Hippocampal tissue homogenates were assayed for Aβ1-40 (F) or Aβ1-42 (G) levels. P value significance is calculated from a one-way ANOVA. The data were expressed as mean ± SEM, *P < 0.05, **P < 0.01 vs. WT mice, #P < 0.05, ##P < 0.01 vs. positive control (APP/PS1 mice without CPPs treatment), n = 3.