Research Paper Volume 12, Issue 13 pp 13477—13487

Hydrostatic pressure induces osteogenic differentiation of adipose-derived mesenchymal stem cells through increasing lncRNA-PAGBC

Figure 6. Schematic of the model. HP induces upregulation of PAGBC, which binds to miR-133b to prevent its suppression on translation of RUNX2, resulting in enhanced RUNX2-mediated osteogenic differentiation of AMSCs.