**Figure 1.** The correlations among concentrations of serum metabolites (**A**) and the correlation matrix between the concentrations of metabolites and cardiovascular disease risk factors (**B**). A partial Spearman correlation analysis was used to calculate the correlation coefficients, adjusting for age and sex. The significance threshold was set at ^{*}*p*<0.05, ^{**}*p*<0.01, and ^{***}*p*<0.001 after correcting for the false discovery rate. Abbreviations: BMI, body mass index; HDL–C, high–density lipoprotein cholesterol; GLU, serum glucose; HTDmed, use of antihypertensive medications; LDL–C, low–density lipoprotein cholesterol; SBP, systolic blood pressure.