Research Paper Volume 12, Issue 13 pp 13571—13582

Altered complexity of resting-state BOLD activity in Alzheimer’s disease-related neurodegeneration: a multiscale entropy analysis

Figure 2. MSE differences across the three groups using voxel-wise ANCOVA, controlled for age, education, head motion, and GM. (A) Significant differences of MSE were observed in multiple brain regions, including four regions in scale = 2 (the right hippocampus, right PCG, right IPL and right SFG), one region in scale = 3 (the right cuneus), and two regions in scale = 4 (the MFG and MOG). All the statistical results were corrected for multiple comparisons (p < 0.05, AlphSim correction). (B) The peak entropy value within each region was extracted and used to examine the differences between each pair of groups (p<0.05, FDR correction). Note: PCG, precentral gyrus; IPL, intraparietal lobe; SFG, superior frontal gyrus; MFG, middle frontal gyrus; MOG, middle occipital gyrus; GM, gray matter. *, p<.05; **, p<.01.