Research Paper Volume 12, Issue 13 pp 13571—13582

Altered complexity of resting-state BOLD activity in Alzheimer’s disease-related neurodegeneration: a multiscale entropy analysis

Figure 3. The comparison of MSE patterns between AD and HC in different time scales using independent two-sample t-test, controlled for age, education, head motion, and GM. (A) In scale = 1 and 2, most of the brain regions showed decreased entropy in AD compared with HC. In scale = 3 and 4, the statistical maps tended to show reversed patterns of MSE. (B) MSE of each region was extracted and showed significant interaction effects of group × scale in the hippocampus, SFG, MFG, and MOG (p < 0.01). Note: PCG, precentral gyrus; IPL, intraparietal lobe; SFG, superior frontal gyrus; MFG, middle frontal gyrus; MOG, middle occipital gyrus; GM, gray matter.