Research Paper Volume 12, Issue 13 pp 13633—13646

Melatonin protects against apoptosis of megakaryocytic cells via its receptors and the AKT/mitochondrial/caspase pathway

Figure 6. Melatonin increases peripheral blood cell counts in the radiation-induced myelosuppression mouse. Mice were treated with melatonin (10 mg/kg/day) or TPO (positive control, 1 μg/kg/day) by injecting intraperitoneally. The injections were performed once a day starting from the day of irradiation. (A) white blood cells count. (B) Platelets count. (C) red blood cells count. The effect of melatonin was similar to TPO. Two-way ANOVA (with a Tukey multiple comparison test) was employed to test for significance. * p< 0.05, ** p< 0.01, n=6. WBC, white blood cells; RBC, red blood cells.