Research Paper Volume 12, Issue 13 pp 13668—13683

CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis


Figure 3. CaMKIIγ was critically required for apoptosis and colony-forming of MM Cells. (A) Representative images and quantification of apoptosis in U266 cells after DOX-induced CAMKIIγ-KO (**P < 0.01). (B) Expression levels of apoptosis-related protein were obviously increased in U266 cells of CaMKIIγ downregulation. Comparison of colony-forming ability of high CaMKIIγ expression (C, **P < 0.01), low CaMKIIγ expression (D, *P < 0.05) and the controls, respectively. Cells were plated in the growth medium in 6-well plates and the colonies were counted under light microscope after roughly 3 weeks.