BBM and WBC158 inhibited the growth of CAMKIIγ-dependent MM in vivo. (A, B) U266 cells were subcutaneously injected into the left groin of nude mice. Mice treated with BBM or WBC158 had smaller tumors than their controls after nearly three weeks. (C, D) Images of xenograft tumors from the indicated groups. (E, F) Body weight of nude mice (no significance). (G, H) Tumor weight (*P < 0.05, **P <0.01).