Figure 4. Exosome lncRNA expression signature for ESCC diagnosis. (A–E) Differences in plasma exosome lncRNAs levels in ESCC patients, esophagitis patients, and healthy controls. Each point represents the mean of triplicate samples. Each P-value was calculated with a nonparametric Mann-Whitney test. ***P<0.001. (F) ROC curve analysis of the combined lncRNA panel in exosomes from ESCC patients and non-cancer controls (including healthy controls and esophagitis patients). Each value is the mean±SD; ***P <0.001.