Research Paper Advance Articles pp 23609—23618

Inhibition of Exo-miR-19a-3p derived from cardiomyocytes promotes angiogenesis and improves heart function in mice with myocardial infarction via targeting HIF-1α

Figure 3. Inhibition of miR-19a-3p promotes angiogenesis and improves heart function in mice with MI. (A) Representative echocardiographic assessment images of heart function of mice with MI. (B) Ejection fractions (EF%) and fractional shortening (%). (C) Western blot analysis of expression level of CD31 in left ventricle of mice. (D) Immunofluorescence staining of ki67 in peri-infarct area of left ventricle. **P < 0.01. All experiments were performed more than 4 biological repeats. Scar bar = 50μm.