**Figure 2.** **Correlation between the questionnaire results and GBM outcomes.** (**A**) Scatter plots demonstrating the correlations of PHQ-9 (left) and GAD-7 (right) scores with the overall survival (OS) times in GBM patients. Pearson correlation analysis was used. The correlation coefficient, 95% confidence interval and *P* value are provided in the upper right corner of each plot. (**B**) Kaplan-Meier analyses of OS in patients with high or low PHQ-9 (left side) or GAD-7 (right side) scores. The OS times differed significantly between patients with higher (red line, n = 38) and lower (blue line, n = 36) PHQ-9 scores; *P* = 0.0172. The OS times also differed significantly between patients with higher (red line, n = 36) and lower (blue line, n = 39) GAD-7 scores; *P* = 0.002. A log-rank (Mantel-Cox) test was used. (**C**) Histogram displaying the differences in PHQ-9 (left side, n ^{male} = 40, n ^{female} = 44, *P* = 0.0378) and GAD-7 (right side, n ^{male} = 40, n ^{female} = 44, *P* = 0.5742) results between male and female GBM patients. Student’s t-test was used for statistical analysis. *, *P* < 0.05. (**D**) Histogram displaying the differences in OS between male GBM patients with high or low PHQ-9 or GAD-7 scores. The OS times differed significantly between male patients with high (red, n = 20) and low (blue, n = 16) PHQ-9 scores (left side); *P* = 0.0003. The OS times also differed significantly between male patients with high (red, n = 21) and low (blue, n = 15) GAD-7 scores (right side); *P* = 0.0006. Student’s t-test was used for statistical analysis; ***, *P* < 0.001. (**E**) Histogram displaying the differences in OS between female GBM patients with high or low PHQ-9 or GAD-7 scores. The OS times did not differ significantly between female patients with high (red, n = 18) and low (blue, n = 21) PHQ-9 scores (left side); *P* = 0.9966. The OS times differed significantly between female patients with high (red, n = 15) and low (blue, n = 24) GAD-7 scores (right side); *P* = 0.0054. Student's t-test was used for statistical analysis; **, *P* < 0.01.