Figure 5. Circ_0043278 targets on miR-638. (A) Putative circ_0043278 binding sites in miR-638; (B) Luciferase reporter plasmid containing wt or mut circ_0043278 was co-transfected into HEK-293 cells with miR-638 or NC mimics. Luciferase activity was determined 24 h after transfection via dual-luciferase assay and normalized to Renilla luciferase activity. Results represent the mean±SD for three independent experiments (**p<0.01, as determined by one-way ANOVA with Bonferroni’s multiple comparisons test).