Research Paper Volume 12, Issue 21 pp 21114—21128

Hsa_circ_0043278 functions as competitive endogenous RNA to enhance glioblastoma multiforme progression by sponging miR-638

Figure 6. MiR-638 inhibitor reverses circ_0043278-shRNA1#-induced glioma cell invasion and migration attenuation. (A, B) U87 and U251 cells were stably transfected with NC or cic_0043278-shRNA1# or co-transfected with cic_0043278-shRNA1# and miR-638 inhibitor. Migration and invasion were evaluated using transwell assays. Results represent the mean±SD for three independent experiments (*p<0.05, **p<0.01, as determined by one-way ANOVA with Bonferroni’s multiple comparisons test). Scale bar = 50 μm in all panels.