Glucose stimulation suppresses miR-21-3p expression. (A) The level of miR-21-3p in the diabetes patients and the healthy controls was measured by qRT-PCR analysis (n=10, per group); (B) qRT-PCR was used to measure MiR-21-3p expression in the skin tissue from mice that received different treatments (n=10, per group); (C) The level of miR-21-3p in fibroblasts was measured at 3 h and 24 h following diabetic stimulation with D-glucose; (D) The level of miR-21-3p in WT and db.db. mice tissues was measured on days 1, 4, and 7 post-wounding. (n=10, per group). Data are presented as the mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.