Figure 3. MiR-21-3p directly targets SPRY1. (A) The luciferase assay results of miR-21-3p and SPRY1; (B) The level of miR-21-3p in the different groups was measured by qRT-PCR; (C) The level of mRNA SPRY1 in fibroblasts was measured at 3 h and 24 h following diabetic stimulation with D-glucose; (D) The level of mRNA SPRY1 in mice tissues was measured on days 1, 4, and 7 post-wounding (n=10, per group). Data are presented as the mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.