Priority Research Paper Volume 12, Issue 13 pp 12441—12467

Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

Figure 1. Kidney function of living kidney donors before and after kidney donation. (A) At start of the study (POD-pre), creatinine levels were significantly higher in the control group compared to the PCR group. Postoperatively, a trend towards lower levels of creatinine was observed in the PCR-group. (B) Taking POD-1 as cut-off value, relative creatinine clearance was significantly improved in the PCR-group at POD2, POD3 and POMo1. (C) Absolute glomerular filtration rate did not significantly differ between the groups. (D) Serum urea levels were significantly lower in the PCR group on POD1 and remained so in the first two postoperative days. (E) Serum Cystatin C concentrations showed no significant differences between the two groups except for a trend of lowering values in PCR-donors on POD3. Values are depicted as median ± interquartile range. PCR = protein and caloric dietary restriction; POD = postoperative day; POMo = postoperative month; eGFR = estimated glomerular filtration rate using the CKD-EPI formula. *=significant values.