Research Paper Volume 12, Issue 15 pp 15446—15461

The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior

class="figure-viewer-img"

Figure 7.

Schematic illustrating the crucial role of the spleen in exacerbating lipopolysaccharide (LPS)-induced increases in systemic inflammation, neuroinflammation, cognitive deficits, and anxiety-like behavior in mice exposed to CRSR. BBB, blood-brain barrier; CRSR, chronic and repeated short-term sleep restriction.