Research Paper Volume 12, Issue 19 pp 19022—19044
Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease
The relationships among drugs, core prognostic genes, and targets. (A–C) The similarity matrix of genomic, proteomic connectivity for compounds with tau >95 in CMap (A), GCP (B) and P100 (C) database. The map was sorted with the strongest perturbagen connections at the top in red. (D) Schematic representation of the association between RNA modification regulators (RNA-MRs), function-related prognostic DEGs and target of compounds with tau>95. Pink squares: RNA-MRs; green cycles: targets; blue diamond: prognostic DEGs; green diamond: prognostic genes as targets. (E) Schematic representation of targets with a direction relationship with RNA-MRs, together with corresponding inhibitors.