Research Paper Volume 12, Issue 19 pp 19022—19044

Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease


The cellular viability and dysregulation of RNA modification regulators (RNA-MRs) in human neuroblastoma cell line SH-SY5Y cells. (AE) Concentration-dependent inhibition of cellular viability by purvalanol A, idarubicin, WZ3146, AZD-8055, TG-101348 (10-8~10-5 mol/L) at 24 h, measured by CCK8 assay. (F) The expression levels of ALYREF, ADAT1, ADAT3, NSUN2, ALKBH5, TET2 detected by quantitative real-time PCR. *p < 0.05, **p < 0.01 versus control group.