Figure 1. Effects of PB2 on pathological changes and renal function (n = 8). Mice were challenged with 10 mg/kg LPS (i.p.) and treated with PB2 (i.g.). 24 h after LPS challenged, mice were sacrificed. HE and PAS (Bar = 50 μm; asterisks: cast, arrowhead: vacuolization, arrow: loss of brush border) (A) and Quantification of tubular injury (D); Serum creatinine (B), Blood urea nitrogen (C). #P < 0.05, ##P ≤ 0.01 compared to control mice; *P ≤ 0.05, **P ≤ 0.01 compared to LPS challenged alone.