Research Paper Volume 12, Issue 15 pp 15638—15655

Protection of procyanidin B2 on mitochondrial dynamics in sepsis associated acute kidney injury via promoting Nrf2 nuclear translocation

Figure 1. Effects of PB2 on pathological changes and renal function (n = 8). Mice were challenged with 10 mg/kg LPS (i.p.) and treated with PB2 (i.g.). 24 h after LPS challenged, mice were sacrificed. HE and PAS (Bar = 50 μm; asterisks: cast, arrowhead: vacuolization, arrow: loss of brush border) (A) and Quantification of tubular injury (D); Serum creatinine (B), Blood urea nitrogen (C). #P < 0.05, ##P ≤ 0.01 compared to control mice; *P ≤ 0.05, **P ≤ 0.01 compared to LPS challenged alone.