Research Paper Volume 12, Issue 15 pp 15638—15655

Protection of procyanidin B2 on mitochondrial dynamics in sepsis associated acute kidney injury via promoting Nrf2 nuclear translocation

Figure 3. Effects of PB2 on mitochondrial biogenesis and fusion/fission (n = 8). The mRNA of AMPK, Sirt1 and PGC-1α (A), OPA1, Mfn2, Drp1 and Fis1 (B); expressions of AMPK, Sirt1, PGC-1α, OPA1, Mfn2, Drp1 and Fis1, and semi-quantification (C, D). #P ≤ 0.05, ##P ≤ 0.01 compared to control mice; *P ≤ 0.05, **P ≤ 0.01 compared to LPS challenged alone.