Research Paper Volume 12, Issue 15 pp 15638—15655

Protection of procyanidin B2 on mitochondrial dynamics in sepsis associated acute kidney injury via promoting Nrf2 nuclear translocation

Figure 4. Effects of PB2 on mitophagy (n = 8). Mitochondrial structure in renal tubular epithelial (Bar = 5 μm) (A); co-localization of anti-LC3 (green)/anti-COX IV (red) antibodies (B) and anti-Pink1 (green)/anti-COX IV (red) antibodies (C) (Bar = 25 μm); the co-localization fluorescence intensity, overlap coefficient and Pearson's correlation of LC3-COX IV and Pink1-COX IV (D–F); expression of Pink1, parking, LC3 and p62, and semi-quantification (G–I). #P ≤ 0.05, ##P ≤ 0.01 compared to control mice; *P ≤ 0.05, **P ≤ 0.01 compared to LPS challenged alone.