Research Paper Volume 12, Issue 17 pp 17380—17392

Identification of a cullin5-RING E3 ligase transcriptome signature in glioblastoma multiforme


Figure 6. Survival analysis based on the impact of the multi-gene PI. (A) Heatmap analysis of the CRL5 components in TCGA-GBM dataset was conducted using the UCSC Xena tool. (B) Survival analysis based on HR was conducted using the GBM-BioDP portal. GBM tissue was classified into proneural (P), neural (N), classical (C) and mesenchymal (M) subtypes based on gene expression patterns [20]. A Cox proportional hazards model was constructed with gene expression of the CRL5 components, SOCS3, RNF7, TCEB1 and TCEB2. We used O-6-methylguanine-DNA methyltransferase (MGMT) methylation status as a covariate. P values are included in the figure.